(R)-Olodaterol Benzyl Ether HCl CAS 869478-13-7(Free Base)
| CAS No. | 869478-13-7(Free Base) |
| Molecular Formula | C28H32N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (R)-Olodaterol Benzyl Ether HCl (C28H32N2O5HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, (R)-Olodaterol Benzyl Ether HCl (CAS 869478-13-7(Free Base), C28H32N2O5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H32N2O5 HCl |
| Molecular Weight | 513.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related R Standards
- Olodaterol Impurity 1 (CAS 78-09-1)
- Olodaterol (CAS 868049-49-4)
- (S)-Olodaterol (CAS 868049-50-7)
- (S)-Olodaterol hydrochloride (CAS 868049-50-7(free base))
- Olodaterol Hydrochloride (CAS 869477-96-3)
- Olodaterol Impurity N6 (CAS 869478-10-4)
- (R)-Olodaterol Benzyl Ether (CAS 869478-13-7)
- Olodaterol impurity 34 (CAS 869493-97-0)
Recommended Standards
- Ulipristal Impurity 7 (CAS 709615-25-8)
- Aztreonam impurity 98 (CAS 71780-86-4)
- Lemborexant Impurity 54 (CAS CATO-C4X-304254)
- Methyl 4-((4-cyano-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)oxy)benzoate (CAS 318469-10-2)
- 5-Bromo-1-(2-methoxyphenyl)pyridin-2(1h)-one (CAS 1823549-22-9)
- Pyridine-2,6-diyldimethanol hydrochloride (CAS 21197-76-2)
- Benzyl 4-(1,3-dioxolan-2-yl)piperidine-1-carboxylate (CAS 773093-01-9)
- 5-(Bromomethyl)-1,3-dihydroisobenzofuran (CAS 188111-48-0)
- 4-(Pyrrolidin-1-yl)-5-(p-tolyl)thieno[2,3-d]pyrimidine (CAS 342595-74-8)
- Insulin Degludec Impurity 19 (CAS CATO-C4X-215719)
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